Time-Intensity Curve measurement

This tool analyzes temporal changes in signal intensity across imaging phases, especially useful in dynamic contrast-enhanced MRI studies like oncology and cardiovascular imaging.

Performing Time-Intensity Curve (TIC)

1. Select the Imaging Series

• Begin by selecting the appropriate imaging series. Typically, this will be a larger multiphase series obtained after the administration of contrast media.
• Note: Some MRI vendors may export post-contrast phases as separated series instead of a single large multiphase series. On CMRAD, you can merge these series by constructing a virtual series using the 4D Tool, which allows you to work with a single continuous dataset. 

2. Preparing for Time-Intensity Curve Analysis

• Once you have selected your series, double-click to enlarge it to a 1x1 layout (optional, but recommended for better visualization).
• Navigate to the Measurement menu and select the Time Intensity Curve Tool. 

3. Series Preloading

• After selecting the TIC tool, the series will automatically preload. Preloading refers to a temporary local download of the DICOM images into your browser. This process is crucial for enabling post-processing and ensuring smooth performance during the TIC analysis.

4. Performing the Analysis

• You can now select and draw multiple regions of interest (ROIs) on the images. The TIC tool will graph the intensity changes over time within these ROIs, allowing for a detailed assessment of tissue response to contrast over time. 
•  Real-time feedback, with the curve, is automatically updated as you adjust the ROIs or move through the different phases.